The NRC’s [Human Health Therapeutics Research Centre] advanced bioprocessing services and equipment ensure that quality is built into your biologics and vaccines.
The NRC’s [Human Health Therapeutics Research Centre] advanced bioprocessing services and equipment ensure that quality is built into your biologics and vaccines. The cell culture pilot plant offers process development and scale-up for the production of biologics and vaccines using CHO, HEK293 and other animal cell expression systems. Our team of cell biologists, purification experts and biochemical engineers have extensive experience in process optimization and scale-up, cell culture in bioreactors, medium development, viral infection processes, recovery, purification, high-performance liquid chromatography (HPLC) and cell-based assays. Our medium development specialists enable you to optimize culture media and develop feeding strategies to improve product yield. We excel at working with monitoring tools to develop control strategies. Our tailored analytical assays ensure a smooth transition from bench-scale process optimization all the way up to production at the 500 L scale. The cell culture pilot plant has been extensively used by biotechnology companies for pilot-scale production and purification of recombinant proteins, viral vectors and vaccines. We facilitate the transfer of optimized cGMP-compatible bioprocesses to the contract manufacturing organization (CMO) of your choice. We can also act as a liaison to Canadian CMOs, and aim to foster a strong and prosperous Canadian biomanufacturing sector. **Please note**: In the 1970s, Dr. Frank Graham developed the HEK293 cell line, which is now widely used for academic research and in the pharmaceutical and biotechnology industries around the world. The NRC has developed proprietary versions of the HEK293 cell line, referred to as HEK293SF-3F6 and HEK293-6E.
Other programs in the same space.
1871
Natural Resources Canada (NRCan)
500 Global
500 Global
